Self-Plagiarism at Harvard: Articles Retracted

 

Reported also at BioTechniques website, the following two articles published by Harvard investigators have been retracted:

 

Article 1: Shuxian Jiang et al., Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood. 2011;117(3):827-38.

 

Article 2: Shuxian Jiang et al., Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. J Biol Chem J Biol Chem. 2010;285(46):35471-35478.

 

Corresponding Author on both articles: Dr. Hava Karsenty Avraham, Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 99 Brookline Ave, 3rd floor, Boston, MA 02215.

According to Blood: “The authors and the journal wish to retract the 20 January 2011 paper cited above, because it contains multiple instances of duplicate (redundant) publication of data, text, and images that are nonessential to the paper. The redundancies are between the above-cited Blood article and the following 12 November 2010 article, published in the Journal of Biologic Chemistry (JBC): Jiang S, Zagozdzon R, Jorda MA, et al. Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. J Biol Chem. 2010;285(46):35471-35478.”

“The authors apologize to the readers, reviewers, and editors of both journals for publishing duplicate data.”

According to Journal of Biological Chemistry indicated on PubMed Central:

 “This article has been withdrawn by the authors”

A comparison of the two papers indicates duplication of Table 1 and extensive duplication of word-for-word text as follows:

Extracted from Journal of Biologic Chemistry: [To study the role of endocannabinoids in hematopoietic stem cell niche, we examined the expression of 2-AG and AEA in bone marrow stromal cells. As shown in Table 1, both 2-AG and AEA were detected in stromal cells, with AEA at 35.2 pg/107 cells and 2-AG at 75.2 ng/107 cells.]

[Understanding the signals that regulate HSCs development and the intrinsic and extrinsic mechanisms that are involved in maintenance of HSC in bone marrow niches are crucial for proper hematopoiesis. Hematopoiesis is a life long process in which HSPCs differentiate into mature blood cells. These HSCs are valuable in a clinical setting for patients requiring hematopoietic repair (31,–37). The current treatment involves hematopoietic stem cell transplantation with HSPCs obtained from mobilized peripheral blood or umbilical cord blood (31). Re-population of hematopoiesis is a multistep process regulated by the ability of HSPCs to migrate, home to the appropriate marrow niches, and differentiate to mature blood cells. Hence, insights into the physiological stimuli as well as external signals that induce HSPC exit from the bone marrow and traffic to peripheral blood is important for proper hematopoiesis repair. Here, we provide new evidence on the involvement of the endocannabinoid system in hematopoiesis by inducing migration and mobilization of HSPCs from the BM niches to blood circulation following exposure to stress inducers such as LPS, or to exogenous cannabinoid agonists. The migration of HSPCs to peripheral circulation may limit tissue damage and contribute to hematopoietic repair. Endocannabinoids may regulate hematopoiesis in the BM by maintaining important HSPC functions such as survival.]

Extracted from Blood: Extracted from Blood: [To study the role of the endocannabinoid system in BM-stromal cells, we examined the expression of endocannabinoids 2-AG and AEA in BM-stromal cells. As shown in Table 1, both 2-AG and AEA were detected with AEA at 35.2 pg/107 cells and 2-AG at 75.2 ng/107cells.]

[Understanding of the signals that regulate HSPC development and the intrinsic and extrinsic mechanisms that are involved in maintenance of HSC in the BM niches are crucial for proper hematopoiesis. Hematopoiesis is a lifelong process in which HSPCs differentiate into mature blood cells. These HSPCs are valuable in a clinical setting for patients requiring hematopoietic repair.21 The current treatment involves hematopoietic stem cell transplantation with HSPCs obtained from mobilized peripheral blood or umbilical cord blood. Repopulation of hematopoiesis is a multistep process that is regulated by the ability of HSPCs to migrate, home to the appropriate marrow niches, and differentiate to mature blood cells. Hence, insights into the physiologic stimuli as well as external signals that induce HSPC exist from the BM, and traffic to peripheral blood is important for proper hematopoiesis repair. In this regard, we provide new evidence on the involvement of the endocannabinoid system in hematopoiesis by inducing migration and mobilization of HSPCs from the BM niches to the blood circulation after exposure to stress inducer, such as LPS, or to exogenous cannabinoid agonists. The migration of HSPCs to the peripheral circulation may limit tissue damage and contribute to hematopoietic repair. …]

 

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